Skip to main content

Patrick Charnay

Development of the nervous system

The genetic control of the development of the vertebrate nervous system is the principal focus of the group headed by Patrick Charnay. Two major orientations are addressed:

  • The morphogenesis of the hindbrain, the part of the neural tube that will give rise to the medulla, the pons and part of the cerebellum in the adult central nervous system;
  • The development of peripheral stem cells from a niche located at the interface between central (CNS) and peripheral (PNS) nervous system and their differentiation and regeneration potential.

Thierion E, Le Men J, Collombet S, Hernandez C, Coulpier F, Torbey P, Thomas-Chollier M, Noordermeer D, Charnay P, Gilardi-Hebenstreit P. Krox20 hindbrain regulation incorporates multiple modes of cooperation between cis-acting elements. PLoS Genet. 2017. Jul 27;13(7):e1006903.

Santos R, Vadodaria KC, Jaeger BN, Mei A, Lefcochilos-Fogelquist S, Mendes APD, Erikson G, Shokhirev M, Randolph-Moore L, Fredlender C, Dave S, Oefner R, Fitzpatrick C, Pena M, Barron JJ, Ku M, Denli AM, Kerman BE, Charnay P, Kelsoe JR, Marchetto MC, Gage FH. Differentiation of Inflammation-Responsive Astrocytes from Glial Progenitors Generated from Human Induced Pluripotent Stem Cells. Stem Cell Reports. 2017 Jun 6;8(6):1757-1769.

Jourdon A, Gresset A, Spassky N, Charnay P, Topilko P, Santos R. Prss56, a novel marker of adult neurogenesis in the mouse brain. Brain Struct Funct. 2016 Dec;221(9):4411-4427.

Gresset A, Coulpier F, Gerschenfeld G, Jourdon A, Matesic G, Richard L, Vallat JM, Charnay P, Topilko P. Boundary Caps Give Rise to Neurogenic Stem Cells and Terminal Glia in the Skin. Stem Cell Reports. 2015 Aug 11;5(2):278-90.

Labalette C, Wassef MA, Desmarquet-Trin Dinh C, Bouchoucha YX, Le Men J, Charnay P, Gilardi-Hebenstreit P. Molecular dissection of segment formation in the developing hindbrain. Development. 2015 Jan 1 ;142(1):185-95.

Bouchoucha, Y.X., Reingruber, J., Labalette-Peaucelle, C., Wassef, M.A., Thierion, E., Holcman , D., Gilardi-Hebenstreit, P. and Charnay, P. Dissection of a positive feedback loop driving cell fate choices in hindbrain patterning. Mol. Syst. Biol. (2013) 9, 690. doi: 10.1038/msb.2013.46.

Zebrafish embryo at 20 somites stage subjected to in situ hybridization (...)
Zebrafish embryo at 20 somites stage subjected to in situ hybridization with different probes: krox20 (orange) labelling rhombomeres 3 and 5, mafB (violet) labelling rhombomeres 5 and 6 and pax2.1 (violet) labelling the midbrain/hindbrain boundary.