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Training / Positions

1986 : CES in industrial microbiology
1995 : DEST in biology , CNAM
1986-1988 : Assistant Engineer at the Rhône Poulenc Research Center, « Tératology in vitro » laboratory
1988-1989 : Assistant Engineer at the Alfred Fournier Institut, « Experimental Syphilis » laboratory
1989-1994 : Assistant Engineer at the Institut Pasteur, INSERM U190, « Human viral oncology » laboratory
1994- : Engineer at the Ecole Normale Supérieure, INSERM U784 ,« Molecular Genetic of Development »

Research topics

Regulation of the activity of the transcription factor Krox20 during development of the nervous system in vertebrates.


Breitburd F., Kirnbauer R., Hubbert N.L., Nonnenmacher B., Trin-Dinh-Desmarquet C., Orth G.,Schiller J.T.and Lowy D.R. Immunization with viruslike particles from cottontail rabbit papillomavirus (CRPV) can protect against expérimental CRPV (1995) infection. J. Virol., 69, 3959-3963.
Topilko P., Levi G., Merlo G., Mantero S., Desmarquet C., Mancardi G. and Charnay P. Differential regulation of the zinc finger genes Krox-20 and Krox-24 (Egr-1) suggests antagonistic roles in Schwann cells. (1997)J. Neurosci Res., 50, 702-712.
Seitanidou T., Schneider-Maunoury S., Desmarquet C., Wilkinson D G., and Charnay P. Krox-20 is a key regulator of rhombomere-specific gene expression in the developing hindbrain.(1997) Mech Dev., 65, 31-42.
Helmbacher F., Pujades C., Desmarquet C., Frain M., Rijli F.M., Chambon P and Charnay P. Hoxa 1 and Krox-20 synergize to control the development of rhombomere 3 (1998). Develop., 125, 4539-4748.
Ghislain, J., Desmarquet-Trin-dinh, C., Jaegle, M., Meijer, D., Charnay, P. and Frain, M. Characterisation of cis-acting sequences reveals a biphasic, axon-dependent regulation of Krox20 during Schwann cell development. (2002). Development, 129, 155-166.
Ghislain, J., Desmarquet-Trin-Dinh, C., Gilardi-Hebenstreit, P., Charnay, P. and Frain, M. Neural crest patterning : autoregulatory and crest-specific elements co-operate for Krox20 transcriptional control (2003). Development, 130, 941-953.
Decker, L., Desmarquet-Trin-Dinh, C., Taillebourg, E., Ghislain, J., Vallat J.-M. and Charnay, P. Peripheral myelin maintenance is a dynamic process requiring constant Krox20 expression. (2006) J. Neuroscience, Sep 20 ;26(38):9771-9.
Pouilhe M., Gilardi-Hebenstreit P., Desmarquet-Trin Dinh C. and Charnay P. Direct regulation of vHnf1 by retinoic acid signalling and several MAF-related factors in the neural tube. (2007) Developmental biology, 309, 344-357.
Wassef, M., Chomette, D., Pouilhe, M., Stedman, A., Havis, E., Desmarquet-Trin Dinh, C., Schneider-Maunoury, S., Gilardi-Hebenstreit, P., Charnay, P. and Ghislain, J. Rostral hindbrain patterning involves direct activation of a Krox20 transcriptional enhancer by Hox/Pbx and Meis factors. (2008). Development, 135(20):3369-78.