Renata SANTOS
Staff scientist (CR1 CNRS)
(33)-1-44-32-35-73
E-Mail
Training
1991. Degree in Biology from University of Lisbon, Portugal
1995. Ph.D. in Molecular Biology with first class honors from University of Lisbon, Portugal
1995-2000. Post-doctoral fellow at the Institut Jacques Monod (Danièle Touati’s lab, Paris) : study of the role of the bacterial superoxide dismutase during the symbiosis of Sinorhizobium meliloti and the leguminous plant alfalfa.
200-2002. Post-doctoral fellow at the Institut Jacques Monod (Jean-Michel Camadro’s lab, Paris) : study of iron homeostasis and oxidative stress in the yeast S. cerevisiae.
2002. Recruited as Investigator (Chargé de Recherche) at the CNRS in France.
2002-2011. Work in the same lab (IJM) on the effect of frataxin-deficiency (that cause a neurodegenerative disease in humans) on oxidative stress response and cell death in yeast and mammalian cells.
2012-. Move to Patrick Charnay’s lab at the ISBN to study adult neuronal stem cells in mice.
Research topics
– Adult neurogenesis
– Cellular oxidative stress response
Recent Publications
– S. Lefevre, C. Brossas, F. Auchère, N. Boggetto, J.M. Camadro and R. Santos (2012) Apn1 AP-endonuclease is essential for the repair of oxidatively damaged DNA bases in yeast frataxin-deficient cells. Hum. Mol. Genet. 21, 4060-4072.
– S. Lefevre, D. Sliwa, P. Rustin, J.M. Camadro and R. Santos (2012) Oxidative stress induces mitochondrial fragmentation in frataxin-deficient cells. Biochem. Biophys. Res. Comms. 418, 336-341.
– D. Sliwa, J. Dairou, J.M. Camadro and R. Santos (2012) Inactivation of mitochondrial aspartate aminotransferase contributes to the respiratory deficit of yeast frataxin-deficient cells. Biochem. J. 441, 945-953.
– S. Lefevre, D. Sliwa, F. Auchère, C. Brossas, C. Ruckenstuhl, N. Boggetto, E. Lesuisse, F. Madeo, J.M. Camadro and R. Santos (2012) The yeast metacaspase is implicated in oxidative stress response in frataxin-deficient cells. FEBS Lett. 586, 143-148.
– Bayot, R. Santos, J.M. Camadro and P. Rustin (2011) Friedreich ataxia : the vicious circle hypothesis revisited. BMC Med. 9, 112.
– Seguin, R. Santos, D. Pain, A. Dancis, J.M. Camadro and E. Lesuisse (2011) Co-precipitation of phosphate and iron limits mitochondrial phosphate availability in Saccharomyces cerevisiae lacking the yeast frataxin homologue (YFH1). J. Biol. Chem. 286, 6071-6079.
– R. Santos, S. Lefevre, D. Sliwa, A. Seguin, J.M. Camadro and E. Lesuisse (2010) Friedreich’s ataxia : molecular mechanisms, redox considerations and therapeutic opportunities. Antioxid. Redox Signal. 13, 651-690.
– Seguin, R. Sutak, A.L. Bulteau, R. Garcia-Serres, J.L. Oddou, S. Lefevre, R. Santos, A. Dancis, J.M. Camadro, J.M. Latour and E. Lesuisse (2010) Evidences that yeast frataxin is not an iron storage protein in vivo. Biochim. Biophys. Acta - Mol. Basis Dis. 1802, 531-538.
