Publications
2011 - 2018
Bhullar S, Denby Wilkes C, Arnaiz O, Nowacki M, Sperling L, Meyer E. A mating-type mutagenesis screen identifies a zinc-finger protein required for specific DNA excision events in Paramecium. Nucleic Acids Res. 2018 ; 46(18) : 9550–9562. doi:10.1093/nar/gky772.
Orias E, Singh DP, Meyer E. Genetics and epigenetics of mating type determination in Paramecium and Tetrahymena. Annu Rev Microbiol. 2017 ; 71:133-156. doi:10.1146/annurev-micro-090816-093342.
Guérin F, Arnaiz O, Boggetto N, Denby Wilkes C, Meyer E, Sperling L, Duharcourt S. Flow-cytometry sorting of nuclei enables the first global characterization of Paramecium germline DNA and transposable elements. BMC Genomics. 2017 ; 18(1):327. doi : 10.1186/s12864-017-3713-7.
Saudemont B, Popa A, Parmley JL, Rocher V, Blugeon C, Necsulea A, Meyer E, Duret L. The fitness cost of mis-splicing is the main determinant of alternative splicing patterns. Genome Biol. 2017 ; 18(1):208. doi:10.1186/s13059-017-1344-6.
Carradec Q, Götz U, Arnaiz O, Pouch J, Simon M, Meyer E, et al. Primary and secondary siRNA synthesis triggered by RNAs from food bacteria in the ciliate Paramecium tetraurelia. Nucleic Acids Res 2015. doi:10.1093/nar/gku1331. /pdf
Marmignon A, Bischerour J, Silve A, Fojcik C, Dubois E, Arnaiz O, et al. Ku-Mediated Coupling of DNA Cleavage and Repair during Programmed Genome Rearrangements in the Ciliate Paramecium tetraurelia. PLoS Genetics 2014 ; 10:e1004552. doi:10.1371/journal.pgen.1004552. /pdf
Marker S, Carradec Q, Tanty V, Arnaiz O, Meyer E. A forward genetic screen reveals essential and non-essential RNAi factors in Paramecium tetraurelia. Nucleic Acids Research 2014 ; 42:7268–80. doi:10.1093/nar/gku223. /pdf
Singh DP, Saudemont B, Guglielmi G, Arnaiz O, Goût J-F, Prajer M, et al. Genome-defence small RNAs exapted for epigenetic mating-type inheritance. Nature 2014 ; 509:447–52. doi:10.1038/nature13318. Selected by Faculty of 1000. /pdf
Chalker DL, Meyer E, Mochizuki K. Epigenetics of Ciliates. Cold Spring Harbor Perspectives in Biology 2013 ; 5:a017764–a017764. doi:10.1101/cshperspect.a017764. /pdf
Arnaiz O, Mathy N, Baudry C, Malinsky S, Aury J-M, Denby Wilkes C, et al. The Paramecium Germline Genome Provides a Niche for Intragenic Parasitic DNA : Evolutionary Dynamics of Internal Eliminated Sequences. PLoS Genetics 2012 ; 8:e1002984. doi:10.1371/journal.pgen.1002984. /pdf
Kapusta A, Matsuda A, Marmignon A, Ku M, Silve A, Meyer E, et al. Highly Precise and Developmentally Programmed Genome Assembly in Paramecium Requires Ligase IV–Dependent End Joining. PLoS Genet 2011 ; 7:e1002049.
doi:10.1371/journal.pgen.1002049. /pdf
Bouhouche K, Gout J-F, Kapusta A, Betermier M, Meyer E. Functional specialization of Piwi proteins in Paramecium tetraurelia from post-transcriptional gene silencing to genome remodelling. Nucleic Acids Research 2011 ;39:4249–64. doi:10.1093/nar/gkq1283. /pdf
2006 - 2010
Arnaiz O, Goût J-F, Bétermier M, Bouhouche K, Cohen J, Duret L, et al. Gene expression in a paleopolyploid : a transcriptome resource for the ciliate Paramecium tetraurelia. BMC Genomics 2010 ; 11:547. doi:10.1186/1471-2164-11-547. /pdf
Marker S, Mouël AL, Meyer E, Simon M. Distinct RNA-dependent RNA polymerases are required for RNAi triggered by double-stranded RNA versus truncated transgenes in Paramecium tetraurelia. Nucl Acids Res 2010 ; 38:4092–107. doi:10.1093/nar/gkq131. /pdf
Beisson J, Betermier M, Bre M-H, Cohen J, Duharcourt S, Duret L, et al. DNA Microinjection into the Macronucleus of Paramecium. Cold Spring Harbor Protocols 2010 ; 2010:pdb.prot5364 – pdb.prot5364. doi:10.1101/pdb.prot5364. /pdf
Baudry C, Malinsky S, Restituito M, Kapusta A, Rosa S, Meyer E, et al. PiggyMac, a domesticated piggyBac transposase involved in programmed genome rearrangements in the ciliate Paramecium tetraurelia. Genes & Development 2009 ; 23:2478–83. doi:10.1101/gad.547309. Selected by Faculty of 1000. /pdf
Duharcourt S, Lepère G, Meyer E. Developmental genome rearrangements in ciliates : a natural genomic subtraction mediated by non-coding transcripts. Trends in Genetics 2009 ; 25:344–50. doi:10.1016/j.tig.2009.05.007. /pdf
Lepere G, Nowacki M, Serrano V, Gout J-F, Guglielmi G, Duharcourt S, et al. Silencing-associated and meiosis-specific small RNA pathways in Paramecium tetraurelia. Nucleic Acids Research 2009 ; 37:903–15. doi:10.1093/nar/gkn1018. /pdf
Gratias A, Lepère G, Garnier O, Rosa S, Duharcourt S, Malinsky S, et al. Developmentally programmed DNA splicing in Paramecium reveals short-distance crosstalk between DNA cleavage sites. Nucleic Acids Res 2008 ; 36:3244–51.
doi:10.1093/nar/gkn154. /pdf
Lepere G, Betermier M, Meyer E, Duharcourt S. Maternal noncoding transcripts antagonize the targeting of DNA elimination by scanRNAs in Paramecium tetraurelia. Genes & Development 2008 ; 22:1501–12. doi:10.1101/gad.473008. /pdf
Duret L, Cohen J, Jubin C, Dessen P, Goût J-F, Mousset S, et al. Analysis of sequence variability in the macronuclear DNA of Paramecium tetraurelia : A somatic view of the germline. Genome Res 2008 ; 18:585–96. doi:10.1101/gr.074534.107. /pdf
Jaillon O, Bouhouche K, Gout J-F, Aury J-M, Noel B, Saudemont B, et al. Translational control of intron splicing in eukaryotes. Nature 2008 ; 451:359–62.
doi:10.1038/nature06495. Selected by Faculty of 1000. /pdf
Meyer E, Chalker DL. Epigenetics of Ciliates. Cold Spring Harbor Laboratory Press 2007:pp. 127–50.
Aury J-M, Jaillon O, Duret L, Noel B, Jubin C, Porcel BM, et al. Global trends of whole-genome duplications revealed by the ciliate Paramecium tetraurelia. Nature 2006 ; 444:171–8. doi:10.1038/nature05230. Selected by Faculty of 1000. /pdf
2001 - 2005
Nowacki M, Zagorski-Ostoja W, Meyer E. Nowa1p and Nowa2p : Novel Putative RNA Binding Proteins Involved in trans-Nuclear Crosstalk in Paramecium tetraurelia. Current Biology 2005 ; 15:1616–28. doi:10.1016/j.cub.2005.07.033. /pdf
Meyer É, Beisson J. Épigénétique : la paramecia comme modèle d’étude. Médecine/sciences 2005 ; 21:377–83. doi:10.1051/medsci/2005214377. /pdf
Garnier O, Serrano V, Duharcourt S, Meyer E. RNA-Mediated Programming of Developmental Genome Rearrangements in Paramecium tetraurelia. Molecular and Cellular Biology 2004 ; 24:7370–9. doi:10.1128/MCB.24.17.7370-7379.2004. /pdf
Zagulski M, Nowak JK, Le Mouël A, Nowacki M, Migdalski A, Gromadka R, et al. High Coding Density on the Largest Paramecium tetraurelia Somatic Chromosome. Current Biology 2004 ; 14:1397–404. doi:10.1016/j.cub.2004.07.029. /pdf
Le Mouel A, Butler A, Caron F, Meyer E. Developmentally Regulated Chromosome Fragmentation Linked to Imprecise Elimination of Repeated Sequences in Paramecia. Eukaryotic Cell 2003 ; 2:1076–90. doi:10.1128/EC.2.5.1076-1090.2003. /pdf
Meyer E, Garnier O. 10 Non-mendelian inheritance and homology-dependent effects in ciliates. Advances in Genetics 2002 ;46:305–37. doi:10.1016/S0065-2660(02)46011-7. /pdf
Kervestin S, Garnier OA, Karamyshev AL, Ito K, Nakamura Y, Meyer E, et al. Isolation and expression of two genes encoding eukaryotic release factor 1 from Paramecium tetraurelia. J Eukaryot Microbiol 2002 ; 49:374–82. doi:10.1111/j.1550-7408.2002.tb00215.x. /pdf
Dessen P, Zagulski M, Gromadka R, Plattner H, Kissmehl R, Meyer E, et al. Paramecium genome survey : a pilot project. Trends in Genetics 2001 ; 17:306–8.
doi:10.1016/S0168-9525(01)02307-1. /pdf
1996 - 2000
Bétermier M, Duharcourt S, Seitz H, Meyer E. Timing of Developmentally Programmed Excision and Circularization of Paramecium Internal Eliminated Sequences. Mol Cell Biol 2000 ; 20:1553–61. doi:10.1128/MCB.20.5.1553-1561.2000. /pdf
Meyer E, Cohen J. Paramecium Molecular Genetics : Functional Complementation and Homology-Dependent Gene Inactivation. Protist 1999 ; 150:11–6. doi:10.1016/S1434-4610(99)70004-0. /pdf
Duharcourt S, Keller A-M, Meyer E. Homology-Dependent Maternal Inhibition of Developmental Excision of Internal Eliminated Sequences in Paramecium tetraurelia. Molecular and Cellular Biology 1998 ; 18:7075–85. /pdf
Meyer E, Butler A, Dubrana K, Duharcourt S, Caron F. Sequence-specific epigenetic effects of the maternal somatic genome on developmental rearrangements of the zygotic genome in Paramecium primaurelia. Mol Cell Biol 1997 ; 17:3589–99. /pdf
Meyer E, Duharcourt S. Epigenetic regulation of programmed genomic rearrangements in Paramecium aurelia. J Eukaryot Microbiol 1996 ; 43:453–61. /pdf
Meyer E, Duharcourt S. Epigenetic Programming of Developmental Genome Rearrangements in Ciliates. Cell 1996 ; 87:9–12. doi:10.1016/S0092-8674(00)81317-3. /pdf
Meyer E, Keller A-M. A Mendelian Mutation Affecting Mating-Type Determination Also Affects Developmental Genomic Rearrangements in Paramecium tetraurelita. Genetics 1996 ; 143:191–202. /pdf
Before 1995
Duharcourt S, Butler A, Meyer E. Epigenetic self-regulation of developmental excision of an internal eliminated sequence on Paramecium tetraurelia. Genes & Development 1995 ; 9:2065–77. doi:10.1101/gad.9.16.2065. /pdf
Keller AM, Le Mouël A, Caron F, Katinka M, Meyer E. The differential expression of the G surface antigen alleles in Paramecium primaurelia heterozygous cells correlates to macronuclear DNA rearrangement. Dev Genet 1992 ; 13:306–17. doi:10.1002/dvg.1020130408. /pdf
Meyer E. Induction of specific macronuclear developmental mutations by microinjection of a cloned telomeric gene in Paramecium primaurelia. Genes Dev 1992 ; 6:211–22. doi:10.1101/gad.6.2.211. /pdf
Caron F, Meyer E. Molecular Basis of Surface Antigen Variation in Paramecia. Annual Review of Microbiology 1989 ; 43:23–42. doi:10.1146/annurev.mi.43.100189.000323. /pdf
Prat A, Katinka M, Caron F, Meyer E. Nucleotide sequence of the Paramecium primaurelia G surface protein : A huge protein with a highly periodic structure. Journal of Molecular Biology 1986 ; 189:47–60. doi:10.1016/0022-2836(86)90380-3. /pdf
Meyer E, Caron F, Baroin A. Macronuclear structure of the G surface antigen gene of Paramecium primaurelia and direct expression of its repeated epitopes in Escherichia coli. Mol Cell Biol 1985 ; 5:2414–22. /pdf
Caron F, Meyer E. Does Paramecium primaurelia use a different genetic code in its macronucleus ? Nature 1985 ; 314:185–8. /pdf
Meyer E, Caron F, Guiard B. Blocking of in vitro translation of Paramecium messenger RNAs is due to messenger RNA primary structure. Biochimie 1984 ; 66:403–12.
