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Cristina Alvarez de Frutos

Post-doctoral

tel : +33 (0)1 44 32 37 22
fax : +33 (0)1 44 32 39 88
alvarez chez biologie.ens.fr

Training
• 1998 : Bsc. in Chemistry at the Universidad Complutense de Madrid (UCM)
• 2002 : Msc. in Biochemistry and Molecular Biology at the UCM
• 2004 : Ph.D. in the Cajal Institute (Madrid, Spain), in the laboratory of Angela Nieto. Project : ‘Generation and analysis of an inducible mouse model for Snail1 transcription factor’
• 2004-2010 : Postdoctoral position in the Neurosciences Institute, CSIC-UMH (Alicante, Spain), in the laboratory of Angela Nieto. Project : ‘Role of Snail1 transcription factor in bone development and homeostasis’
• 2010 to date : Postdoctoral position in the Ecole Normale Supèrieure, IBENS-INSERM-CNRS (Paris, France), in the Laboratory of Sonia Garel (Brain Development and Plasticity Group). Project : ‘Analysis of Cajal-Retzius cells distribution and its input on cortical lamination’

Research Topics
• Cell migration in the ventral telencephalon, focusing on Cajal-Retzius cells
• Mechanisms involved in the expansion and folding of the cerebral cortex across evolution

Publications
• Machicoane M, De Frutos CA, Fink J, Rocancourt M, Lombardi Y, Garel S, Piel M and Echard A (2014) SLK-dependent activation do ERMs controls LGN-NuMA localization and spindle orientation. J Cell Biol. 205(6), 791-799.
• Martinez-Frias ML, Egües J, Puras A, Hualde J, De Frutos CA, Bermejo E, Nieto MA and Martinez S (2011) Thanatophoric dysplasia type II with encephalocele and semilobar holoprosencephaly : insights to its pathogenesis. Am. J. Med. Genet. 155A(1), 197-202.
• Franco DL, Mainez J, Vega S, Sancho P, Murillo MM, De Frutos CA, Del Castillo G, Lopez-Blau C, Fabregat I and Nieto MA (2010) Snail1 suppresses TGF-b-induced apoptosis and is sufficient to trigger EMT in hepatocytes. J. Cell Sci. 15 ;123(Pt 20), 3467-3477.
• Martinez-Frias ML, De Frutos CA, Bermejo E and Nieto MA ; ECEMC Working Group (2010) Review of the recently defined mechanisms underlaying thanatophoric dysplasia and their potential therapeutic implications for achondroplasia. Am. J. Med. Genet. A. 152A(1), 245-255.
• De Frutos CA, Dacquin R, Vega S, Jurdic P, Machuca-Mallet I and Nieto MA. (2009) Snail1 controls bone mass by regulating Runx2 and VDR expression during osteoblast differentiation. EMBO J 28, 686-696.
• De Frutos CA, Vega S, Manzanares M, Flores JM, Huertas H, Martínez-Frías ML and Nieto MA. (2007) Snail1 is a transcriptional effector of FGFR3 signaling during chondrogenesis and achondroplasias. Dev. Cell 13, 872-883.
• Morales AV, Acloque H, Ocaña OH, De Frutos CA, Gold V and Nieto MA. (2007) Snail genes at the crossroad s of symmetric and asymmetric processes in the developing mesoderm. EMBO Rep. 8, 104-109.
• Boutet A, De Frutos CA, Maxwell PH, Mayol MJ, Romero J and Nieto MA. (2006) Snail activation disrupts tissue homeostasis and induces fibrosis in the adult kidney. EMBO, J 25, 5603-5613.
• Locascio A, Vega S, De Frutos CA, Manzanares M, Nieto MA. (2002) Biological Potential of a Functional Human SNAIL Retrogene. J Biol Chem 277(41), 38803-38809.
• Rodríguez-Fernández JL, Sánchez-Martín L, De Frutos CA, Sancho D, Robinson M, Sánchez-Madrid F, Cabañas C. (2002) LFA-1 Integrin and the Microtubular Cytoskeleton are in the Ca-mediated regulation of the activity of the Tyrosine Kinase PYK-2 in T cells. J Leukoc Biol 71(3), 520-530.