Publications
GluD1 binds GABA and controls inhibitory plasticity
Piot L , Heroven C#, Bossi S#, Zamith J, Malinauskas T, Johnson C, Wennagel D, Stroebel D, Charrier C, Aricescu A.R*, Mony L* and Paoletti P.*
# Co-second author
* Co-last author.
Science. Dec 22 ; 382(6677):1389-1394
doi : 10.1126
Mechanisms of NMDA receptor regulation
Mony L and Paoletti P.
Curr Opin Neurobiol. 2023 Nov 20 ; 83:102815.
doi : 10.1016
Excitatory GluN1/GluN3A glycine receptors (eGlyRs) in brain signaling
Bossi S, Pizzamiglio L, Paoletti P.
Trends Neurosci. 2023 Aug ; 46(8):667-681
doi : 10.1016/j.tins.2023.05.002.Review
Zn2+ inhibits spatial memory and hippocampal place cell representation through high-affinity binding to the NMDA receptor GluN2A subunit
Sikora J, Di Bisceglie Caballero S, Reiss D, Kieffer BL, Paoletti P, Jacob PY, Ouagazzal AM.
iScience. 2022 Oct 13 ; 25(11):105355
doi : 10.1016/j.isci.2022.105355
GluN3A excitatory glycine receptors control adult cortical and amygdalar circuits
Bossi S#, Dhanasobhon D#, Ellis-Davies G.C.R, Frontera J, de Brito Van Velze M, Lourenco J, Murillo A, Lujan R, Casado M, Perez-Otano I, Bacci A, Popa D, Paoletti P* and Rebola N*
Neuron. 3 Aug 22 ; 110(15):2438-2454.e8
doi : 10.1016/j.neuron.2022.05.016
# Co-first author.
* Co-last author.
Activity-dependent modulation of NMDA receptors by endogenous zinc shapes dendritic function in cortical neurons
Morabito A, Zerlaut Y, Serraz B, Sala R, Paoletti P and Rebola N.
Cell Reports. 2022 Feb 22 ;38(8):110415.
doi : 10.1016/j.celrep.2022.110415.
Positive allosteric modulation of NMDA receptors : mechanisms, physiological impact and therapeutic potential
Geoffroy C, Paoletti P* and Mony L.*
The Journal of Physiology. 2022 Jan ;600(2):233-259.
doi : 10.1113/JP280875
* Co-last author
Control of protein synthesis and memory by GluN3A-NMDA receptors through inhibition of GIT1/mTORC1 assembly
Conde-Dusman M.J, Dey P.N, Elía-Zudaire O, Rabaneda L.G, García-Lira C, Grand T, Briz V, Velasco E.R, Andero R, Niñerola S, Barco A, Paoletti P, Wesseling J.F, Gardoni F, Tavalin S.J and Perez-Otaño I.
Elife. 2021 Nov 17 ;10:e71575.
doi : 10.7554/eLife.71575
GluN2A and GluN2B NMDA receptors use distinct allosteric routes.
Tian M#, Stroebel D#, Piot L, David M, Ye S* and Paoletti P*
Nature Communications. 2021 Aug 5 ;12(1):4709.
doi : 10.1038/s41467-021-25058-9
# Co-first author.
* Co-last author.
Gating mechanism and a modulatory niche of human GluN1-GluN2A NMDA receptors.
Wang H, Lv S, Stroebel D, Zhang J, Pan Y, Huang X, Zhang X, Paoletti P and Zhu S.
Neuron. 2021 Aug 4 ;109(15):2443-2456.e5
doi : 10.1016/j.neuron.2021.05.031
Glycine agonism in ionotropic glutamate receptors.
Stroebel D, Mony L and Paoletti P.
Neuropharmacology. 2021 Aug 1 ;193:108631
doi : 10.1016/j.neuropharm.2021.108631.
Architecture and function of NMDA receptors : an evolutionary perspective.
Stroebel D and Paoletti P.
J Physiol. 2021 May ;599(10):2615-2638
doi : 10.1113/JP279028
Photochemical Control of Drug Efficacy : A Comparison of Uncaging and Photoswitching Ifenprodil on NMDA Receptors.
Thapaliya E.R*, Mony L*, Sanchez R, Serraz B, Paoletti P, Ellis‐Davies G.
*co-first author
ChemPhotoChem. 2021 Fev 04.
doi : 10.1002/cptc.202000240
Early correction of synaptic long-term depression improves abnormal anxiety-like behavior in adult GluN2B-C456Y-mutant mice.
Shin W, Kim K, Serraz B, Cho Y.S, Kim D, Kang M, Lee E-J, Lee H, Bae Y.C, Paoletti P and Kim E.
PLoS Biol. 2020 Apr 30 ;18(4):e3000717.
doi : 10.1371/journal.pbio.3000717.
Photocontrol of Metabotropic Glutamate Receptors : When One Agonist Is Not Enough, Make It Two.
Mony L and Paoletti P.
Neuron. 2020 Fev 05 ;105(3):395-397
doi:10.1016/j.neuron.2020.01.013
Synaptic zinc contributes to motor and cognitive deficits in 6-hydroxydopamine mouse models of Parkinson’s disease.
Sikora J, Kieffer BL, Paoletti P, Ouagazzal AM.
Neurobiol Dis. 2019 Nov 20:104681.
doi : 10.1016/j.nbd.2019.104681.
Control of aversion by glycine-gated GluN1/GluN3A NMDA receptors in the adult medial habenula.
Otsu Y, Darcq E, Pietrajtis K, Mátyás F, Schwartz E, Bessaih T, Abi Gerges S, Rousseau CV, Grand T, Dieudonné S, Paoletti P, Acsády L, Agulhon C, Kieffer BL, Diana MA.
Science. 2019 Oct 11 ;366(6462):250-254.
doi : 10.1126/science.aax1522.
Optical control of neuronal ion channels and receptors.
Paoletti P, Ellis-Davies G and Mourot A.
Nat Rev Neurosci. 2019 Sep ;20(9):514-532.
doi : 10.1038/s41583-019-0197-2.
An inter-dimer allosteric switch controls NMDA receptor activity.
Esmenjaud JB, Stroebel D, Chan K, Grand T, David M, Wollmuth LP, Taly A, Paoletti P.
EMBO J. 2019 Jan 15 ;38(2):e99894.
doi : 10.15252/embj.201899894
Unmasking GluN1/GluN3A excitatory glycine NMDA receptors.
Grand T, Abi Gerges S, David M, Diana MA, Paoletti P.
Nat Commun. 2018 Nov 13 ;9(1):4769.
doi : 10.1038/s41467-018-07236-4.
Higher ambient synaptic glutamate at inhibitory versus excitatory neurons differentially impacts NMDA receptor activity.
Yao L, Grand T, Hanson J, Paoletti P, Zhou Q.
Nat Commun. 2018 Oct 1 ;9(1):4000.
doi : 10.1038/s41467-018-06512-7.
Probing ion channel structure and function using light-sensitive amino acids.
Klippenstein V, Mony L, Paoletti P.
Trends Biochem Sci. 2018 Jun ;43(6):436-451.
doi : 10.1016/j.tibs.2018.02.012. Epub 2018 Apr 10.
Triheteromeric NMDA receptors : from structure to synaptic physiology.
Stroebel D, Casado M, Paoletti P.
Curr Opin Physiol. 2018 Apr ;2:1-12.
doi : 10.1016/j.cophys.2017.12.004. Epub 2017 Dec 19.
Co-agonists differentially tune GluN2B-NMDA receptor trafficking at hippocampal synapses.
Ferreira JS, Papouin T, Ladépêche L, Yao A, Langlais VC, Bouchet D, Dulong J, Mothet JP, Sacchi S, Pollegioni L, Paoletti P, Oliet SHR, Groc L.
Elife. 2017 Jun 9 ;6. pii : e25492. doi : 10.7554/eLife.25492.
Optocontrol of glutamate receptor activity by single side-chain photoisomerization.
Klippenstein V, Hoppmann C, Ye S, Wang L, Paoletti P.
Elife. 2017 May 23 ;6. pii : e25808. doi : 10.7554/eLife.25808.
Altered zinc sensitivity of NMDA receptors harboring clinically-relevant mutations.
Serraz B, Grand T, Paoletti P.
Neuropharmacology. 2016 Oct ;109:196-204.
doi : 10.1016/j.neuropharm.2016.06.008. Epub 2016 Jun 7.
A Novel Binding Mode Reveals Two Distinct Classes of NMDA Receptor GluN2B-selective Antagonists.
Stroebel D#, Buhl DL#, Knafels JD, Chanda PK, Green M, Sciabola S, Mony L, Paoletti P*, Pandit J*.
Mol Pharmacol. 2016 May ;89(5):541-51. doi : 10.1124/mol.115.103036. Epub 2016 Feb 24.
# Co-first author.
* Co-last author.
Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function.
Hackos DH, Lupardus PJ, Grand T, Chen Y, Wang TM, Reynen P, Gustafson A, Wallweber HJ, Volgraf M, Sellers BD, Schwarz JB, Paoletti P, Sheng M, Zhou Q, Hanson JE.
Neuron. 2016 Mar 2 ;89(5):983-99. doi : 10.1016/j.neuron.2016.01.016. Epub 2016 Feb 11.
Presynaptic NMDA receptors : Roles and rules.
Bouvier G, Bidoret C, Casado M, Paoletti P.
Neuroscience. 2015 Dec 17 ;311:322-40. doi : 10.1016/j.neuroscience.2015.10.033. Epub 2015 Oct 24. Review.
Editorial overview : neurosciences : targeting glutamatergic signaling in CNS diseases : new hopes ?
Paoletti P, Pin JP.
Curr Opin Pharmacol. 2015 Feb ;20:iv-vi. doi : 10.1016/j.coph.2015.01.001. Epub 2015 Jan 15.
Controlling NMDA receptor subunit composition using ectopic retention signals.
Stroebel D, Carvalho S, Grand T, Zhu S, Paoletti P.
J Neurosci. 2014 Dec 10 ;34(50):16630-6. doi : 10.1523/JNEUROSCI.2736-14.2014.
Allosteric modulators of NMDA receptors : multiple sites and mechanisms.
Zhu S, Paoletti P.
Curr Opin Pharmacol. 2014 Nov 12 ;20C:14-23. doi : 10.1016/j.coph.2014.10.009. Review.
Neuroscience : A structure to remember.
Stroebel D, Paoletti P.
Nature. 2014 Jul 10 ;511(7508):162-3. doi : 10.1038/511162a.
Zinc dynamics and action at excitatory synapses.
Vergnano AM#, Rebola N#, Savtchenko LP#, Pinheiro PS, Casado M, Kieffer BL, Rusakov DA, Mulle C*, Paoletti P*.
Neuron. 2014 Jun 4 ;82(5):1101-14. doi : 10.1016/j.neuron.2014.04.034.
# Co-first author.
* Co-last author.
Genetically encoding a light switch in an ionotropic glutamate receptor reveals subunit-specific interfaces.
Zhu S#, Riou M#, Yao CA, Carvalho S, Rodriguez PC, Bensaude O, Paoletti P*, Ye S*.
PNAS (USA). 2014 Apr 22 ;111(16):6081-6.
doi : 10.1073/pnas.1318808111. Epub 2014 Apr 8.
# Co-first author.
* Co-last author.
NMDA receptor subunit diversity : impact on receptor properties, synaptic plasticity and disease.
Paoletti P, Bellone C, Zhou Q.
Nat Rev Neurosci. 2013 Jun ;14(6):383-400. doi : 10.1038/nrn3504. Review.
PMID : 23686171 [PubMed - indexed for MEDLINE]
Allosteric signaling and dynamics of the clamshell-like NMDA receptor GluN1 N-terminal domain.
Zhu S, Stroebel D, Yao CA, Taly A, Paoletti P.
Nat Struct Mol Biol. 2013 Apr ;20(4):477-85. doi : 10.1038/nsmb.2522. Epub 2013 Mar 3.
Expanding the genetic code in Xenopus laevis oocytes.
Ye S, Riou M, Carvalho S, Paoletti P.
Chembiochem. 2013 Jan 21 ;14(2):230-5.
Visualization of structural changes accompanying activation of N-methyl-D-aspartate (NMDA) receptors using fast-scan atomic force microscopy imaging.
Suzuki Y, Goetze TA, Stroebel D, Balasuriya D, Yoshimura SH, Henderson RM, Paoletti P, Takeyasu K, Edwardson JM.
J Biol Chem. 2013 Jan 11 ;288(2):778-84.
Positive modulation of a Cys-loop acetylcholine receptor by an auxiliary transmembrane subunit.
Boulin T, Rapti G, Briseño-Roa L, Stigloher C, Richmond JE, Paoletti P, Bessereau JL.
Nat Neurosci. 2012 Oct ;15(10):1374-81. doi : 10.1038/nn.3197. Epub 2012 Aug 26.
An alternating GluN1-2-1-2 subunit arrangement in mature NMDA receptors.
Riou M, Stroebel D, Edwardson JM, Paoletti P.
PLoS One. 2012 ;7(4):e35134. doi : 10.1371/journal.pone.0035134. Epub 2012 Apr 6.
Synaptic neurotransmitter-gated receptors.
Smart TG, Paoletti P.
Cold Spring Harb Perspect Biol. 2012 Mar 1 ;4(3
Confocal microscopy imaging of NR2B-containing NMDA receptors based on fluorescent ifenprodil-like conjugates.
Marchand P, Becerril-Ortega J, Mony L, Bouteiller C, Paoletti P, Nicole O, Barré L, Buisson A, Perrio C.
Bioconjug Chem. 2012 Jan 18 ;23(1):21-6.
The neurophysiology and pathology of brain zinc.
Sensi SL, Paoletti P, Koh JY, Aizenman E, Bush AI, Hershfinkel M.
J Neurosci. 2011 Nov 9 ;31(45):16076-85.
Zinc alleviates pain through high-affinity binding to the NMDA receptor NR2A subunit.
Nozaki C#, Vergnano AM#, Filliol D, Ouagazzal AM, Le Goff A, Carvalho S, Reiss D, Gaveriaux-Ruff C, Neyton J, Paoletti P*, Kieffer BL*.
Nat Neurosci. 2011 Jul 3 ;14(8):1017-22.
# Co-first author.
* Co-last author.
Molecular basis of positive allosteric modulation of GluN2B NMDA receptors by polyamines.
Mony L, Zhu S, Carvalho S, Paoletti P.
EMBO J. 2011 Jun 17 ;30(15):3134-46.
Molecular basis of NMDA receptor functional diversity.
Paoletti P.
Eur J Neurosci. 2011 Apr ;33(8):1351-65. Review.
Biological roles of trace elements in the brain with special focus on Zn and Fe.
Bohic S, Ghersi-Egea JF, Gibon J, Paoletti P, Arnaud J, Hunot S, Boom A, Bouron A.
Rev Neurol (Paris). 2011 Apr ;167(4):269-79. Review.
Functional evidence for a twisted conformation of the NMDA receptor GluN2A subunit N-terminal domain.
Stroebel D, Carvalho S, Paoletti P.
Neuropharmacology. 2011 Jan ;60(1):151-8
Identification of a novel NR2B-selective NMDA receptor antagonist using a virtual screening approach.
Mony L, Triballeau N, Paoletti P, Acher FC, Bertrand HO.
Bioorg Med Chem Lett. 2010 Sep 15 ;20(18):5552-8.
Fonctionnement des récepteurs-canaux du glutamate : des protéines responsables de la transmission synaptique excitatrice.
Gielen M.
Médecine Sciences, vol. 26, 65-72. Revue.
Zinc in the physiology and pathology of the CNS.
Sensi SL, Paoletti P, Bush AI, Sekler I.
Nat Rev Neurosci. 2009 Nov ;10(11):780-91. Review.
Allosteric modulators of NR2B-containing NMDA receptors : molecular mechanisms and therapeutic potential.
Mony L, Kew JN, Gunthorpe MJ, Paoletti P.
Br J Pharmacol. 2009 Aug ;157(8):1301-17. Review.
Mechanism of differential control of NMDA receptor activity by NR2 subunits.
Gielen M, Siegler Retchless B, Mony L, Johnson JW, Paoletti P.
Nature. 2009 Jun 4 ;459(7247):703-7.
Eight genes are required for functional reconstitution of the Caenorhabditis elegans levamisole-sensitive acetylcholine receptor.
Boulin T#, Gielen M#, Richmond JE, Williams DC, Paoletti P*, Bessereau JL*.
PNAS (USA). 2008 Nov 25 ;105(47):18590-5.
# Co-first author.
* Co-last author.
Structural basis of NR2B-selective antagonist recognition by N-methyl-D-aspartate receptors.
Mony L, Krzaczkowski L, Leonetti M, Le Goff A, Alarcon K, Neyton J, Bertrand HO, Acher F, Paoletti P.
Mol Pharmacol. 2009 Jan ;75(1):60-74
Reactive derivatives for affinity labeling in the ifenprodil site of NMDA receptors.
Alarcon K, Martz A, Mony L, Neyton J, Paoletti P, Goeldner M, Foucaud B.
Bioorg Med Chem Lett. 2008 May 1 ;18(9):2765-70.
Zinc at glutamatergic synapses.
Paoletti P, Vergnano AM, Barbour B, Casado M.
Neuroscience. 2009 Jan 12 ;158(1):126-36.
Structural rearrangements of NR1/NR2A NMDA receptors during allosteric inhibition.
Gielen M, Le Goff A, Stroebel D, Johnson JW, Neyton J, Paoletti P.
Neuron. 2008 Jan 10 ;57(1):80-93.
A startling role for synaptic zinc.
Kay AR, Neyton J, Paoletti P.
Neuron. 2006 Nov 22 ;52(4):572-4. Review.
NMDA receptor subunits : function and pharmacology.
Paoletti P, Neyton J.
Curr Opin Pharmacol. 2007 Feb ;7(1):39-47. Review.
Relating NMDA receptor function to receptor subunit composition : limitations of the pharmacological approach.
Neyton J, Paoletti P.
J Neurosci. 2006 Feb 1 ;26(5):1331-3.
Modulation of triheteromeric NMDA receptors by N-terminal domain ligands.
Hatton CJ, Paoletti P.
Neuron. 2005 Apr 21 ;46(2):261-74.
The micromolar zinc-binding domain on the NMDA receptor subunit NR2B.
Rachline J, Perin-Dureau F, Le Goff A, Neyton J, Paoletti P.
J Neurosci. 2005 Jan 12 ;25(2):308-17.
Identification of critical residues in the amino terminal domain of the human NR2B subunit involved in the RO 25-6981 binding pocket.
Malherbe P, Mutel V, Broger C, Perin-Dureau F, Kemp JA, Neyton J, Paoletti P, Kew JN.
J Pharmacol Exp Ther. 2003 Dec ;307(3):897-905. Epub 2003 Oct 8.
Mapping the binding site of the neuroprotectant ifenprodil on NMDA receptors.
Perin-Dureau F, Rachline J, Neyton J, Paoletti P.
J Neurosci. 2002 Jul 15 ;22(14):5955-65.
High-affinity Zn block in recombinant N-methyl-D-aspartate receptors with cysteine substitutions at the Q/R/N site.
Amar M, Perin-Dureau F, Neyton J.
Biophys J. 2001 Jul ;81(1):107-16.
Molecular organization of a zinc binding n-terminal modulatory domain in a NMDA receptor subunit.
Paoletti P, Perin-Dureau F, Fayyazuddin A, Le Goff A, Callebaut I, Neyton J.
Neuron. 2000 Dec ;28(3):911-25.
Four residues of the extracellular N-terminal domain of the NR2A subunit control high-affinity Zn2+ binding to NMDA receptors.
Fayyazuddin A1, Villarroel A, Le Goff A, Lerma J, Neyton J.
Neuron. 2000 Mar ;25(3):683-94.
